opi do you sea what i sea Synaptotagmin-1 (Syt1) acts as a Ca2+ sensor for neurotransmitter release through its C2 domains.It has been proposed that Syt1 promotes SNARE-dependent fusion mainly through its C2B domain, but the underlying mechanism is poorly understood.In this study, we show that the C2B domain interacts simultaneously with acidic mem
Many functional materials are difficult to analyse weboost splitter by scanning transmission electron microscopy (STEM) on account of their beam sensitivity and low contrast between different phases.The problem becomes even more severe when thick specimens need to be investigated, a situation that is common for materials that are ordered from the n
There is a long running debate on the significance of weboost splitter ethnic residential segregation levels in Britain.These phenomena have been related to the extent of community cohesion in British cities, and particularly to the riots of 2001 in the north of England.Further light is cast on these issues by examining ethnic segregation by age in
Cellular protein homeostasis (proteostasis) plays an essential role in regulating the folding, sequestration, and turnover of misfolded proteins via a network of chaperones and clearance factors.Previous work has shown that misfolded proteins are spatially sequestered into membrane-less compartments in the cell as part of the proteostasis process.S